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M9460552.TXT
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1994-06-25
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Document 0552
DOCN M9460552
TI Lichenoid photoeruptions in human immunodeficiency virus infection.
DT 9408
AU Berger TG; Dhar A; Department of Dermatology, University of California,
San; Francisco.
SO Arch Dermatol. 1994 May;130(5):609-13. Unique Identifier : AIDSLINE
MED/94234739
AB BACKGROUND: The clinical features of lichenoid eruptions in the setting
of human immunodeficiency virus (HIV) infection are poorly described.
Idiopathic lichen planus is rarely reported. All patients (n = 32) with
a histologic diagnosis of a lichenoid eruption or photodermatitis at the
University of California, San Francisco, over a 15-month period were
reviewed and studied. OBSERVATIONS: Twelve of the 32 patients were HIV
infected, and all 12 had photodistributed eruptions. Ten of 12 patients
had received photosensitizing medication (usually nonsteroidal
anti-inflammatory drugs or sulfamethoxazole/trimethoprim) at the onset
of eruption. Most patients were black (10 of 12), and all had acquired
immunodeficiency syndrome and a helper T-cell count of less than 50
cells per cubic milliliter. Nine patients had lichenoid eruptions, two
showed histopathologic features of lichen niditus, and one had a
photodistributed subacute dermatitis. Two patients with lichenoid
eruptions developed marked depigmentation. No cases of lichen planus
were found in HIV-infected persons. CONCLUSION: Lichenoid photoeruptions
are seen in advanced HIV disease (CD4, < 0.05 x 10(9)L), and black
patients are disproportionately affected. Idiopathic lichen planus in
HIV-infected patients seems to be less common than lichenoid
photoeruptions. Previously reported cases of idiopathic lichen planus in
HIV-infected patients may represent lichenoid photodermatitis.
DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult Aged Female
Human Lichenoid Eruptions/*COMPLICATIONS/PATHOLOGY Male Middle Age
Photosensitivity Disorders/*COMPLICATIONS/PATHOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).